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Webinar: Diagnosis and Treatment of Canine Chronic Hepatitis

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A free online class brought to you by Bioguard

Get familiar with canine chronic hepatitis. Sponsored by Bioguard Corporation and presented by Dr. Hung-Shi Chio, this is the next webinar you don't want to miss it.

Access to the on-demand recording is FREE
Obtain a CERTIFICATE of attendance



Chronic hepatitis (CH) is characterized by hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration, and fibrosis. The diagnosis and treatment of CH in the dog is a complex process that requires integration of clinical presentation with clinical pathology, diagnostic imaging, and hepatic biopsy. This webinar will include review, diagnosis and treatment of this disease.


Dr. Hung-Shi Chiou graduated from the National Taiwan University in Taiwan, obtaining his master’s degree in veterinary pathology. He is a board-certified veterinarian and veterinary pathologist in Taiwan with expertise in diagnostic pathology, surgical pathology, and lab animal pathology

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Aug. 30

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8 PM – 9 PM

Taipei Local Time

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Certificate of Attendance

eCertificate will be issued to the registered attendants joining the webinar for at least 50 minutes.

How to Join: Three Options:

Option 1: Watch via ZOOM

You can join us live directly via Zoom by simply registering. Please note that we will send you the link that is unique to you and should not be shared with anyone.

Option 2: Watch on our FACEBOOK Page

Follow our Facebook page and join us live during the webinar.

Option 3: Watch at your LEISURE

Registering to attend this webinar will also gain you access to the on-demand recording, which will be available 24 hours later.


We look forward to seeing you at this event.

Happy Learning!

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In cats, ’mucosal’ mycoplasma infections typically cause ocular and respiratory disease, and less frequently neurological or joint disease. These Mycoplasma species are distinct to the haemotropic mycoplasmas that target red blood cells, causing hemolytic anemia in cats. Mycoplasma felis is typically associated with Upper Respiratory Tracy Disease (URTD) in cats.


M. felis is mainly transmitted from an infected cat to an in-contact one by aerosol, but also by grooming. Stresses, including overcrowding environment, concurrent respiratory viral infections and poor hygienic situations, may promote transmission of the infection between cats.

Clinical symptoms

Mycoplasma felis is typically associated with URTD but sometimes it may be associated with lower respiratory tract infections.
Common clinical signs include clear or coloured discharge from the eyes or nose, coughing, sneezing, conjunctivitis, chemosis, lethargy and anorexia. Lower respiratory tract infections can result in pneumonia with fever, cough, tachypnoea, and lethargy.


Culture of mycoplasmas can be used to demonstrate infection, but it takes time for culture and rapid transport of samples to the laboratory is required. Demonstration of organisms via real-time PCR is increasingly being used to circumvent the difficulties with culture,In infected cats, M. felis can be detected by real-time PCR using ocular/ nasopharyngeal swab. The BIOGUARD Qmini PCR SYSTEM offers a versatile way of obtaining nucleic acid for PCR through its magnetic bead technology. In just under 10 minutes, nucleic acid samples are purified and ready for use. Additionally, the system includes a pre-made lyophilized powder PCR reaction mixer and pre-calibrated PCR protocol, resulting in PCR outcomes in 90 minutes.


Antimicrobial therapy is commonly used to treat mycoplasma respiratory infections. Doxycycline is a good first line agent because it is well tolerated by cats and relatively narrow in spectrum. The recommended dose is 5 mg/kg, PO, q12h or 10 mg/kg, PO, q24 (Lappin et al., 2017). Oxytetracycline or chlortetracycline ophthalmic ointment can be used q6h in addition to topical treatment.

To learn more about Qmini PCR, click here
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Encephalitozoon cuniculi is a microsporidial, unicellular, spore-forming, obligate intracellular parasite. It can invade the host's central nervous system, kidneys, crystals, etc. E. cuniculi affects rabbits by causing damage to the brain, nervous system, kidneys and other important organs. E. cuniculi pose a zoonotic risk to immune compromised humans. In addition, it can infect various mammals, such as rabbits, rats, mice, horses, foxes, cats, dogs, muskrats, leopards, and baboons.

Transmission and Life Cycle

E. cuniculi has a direct life cycle with both horizontal and vertical (transplacental) transmission. In rabbits, the common routes of natural horizontal infection are via the ingestion of contaminated food or water or, less commonly, via inhalation of spores.

After ingestion, the spores invade enterocytes and then spread through bloodstream or the lymphatic system. Then, it is carried into the blood circulation to target organs (kidney, central nervous system, eye, liver, and heart) where it causes inflammation. Antibody can be detected 2-3 weeks after infection, and IgM are usually detectable up to 18 weeks post-exposure. Spores are passed in the urine of rabbits, beginning around 35 days after infection, and continue to be excreted for 2 to 3 months

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Clinical signs

When E. cuniculi infects the rabbits, the common clinical signs include head tilt (vestibular disease), hind limb paralysis (weakness of the hind limbs), urinary incontinence, renal failure, cloudy eyes (anterior uveitis), cloudy lenses of the eyes (cataracts), or even blindness.


Clinical diagnosis of encephalitozoonosis can be challenge because of the following reasons. 1. Serologic evidence is strong evidence of infection but not indicative of clinicalsigns. 2. Seroconversion does not result in a protective response for the patient. 3. Histologic severity and distribution of lesions are not directly correlated with the severity of clinical signs. 4. Most infected rabbits are asymptomatic or carriers.

Diagnostic methods of encephalitozoonosis include:

Histopathology- histological examination combined with special staining, or concentrated urine for cytological microsporidia detection

Serology- indirect immune fluorescence antibody test, direct agglutination test, ELISA, western blot

Molecular diagnosis- PCR


Bioguard’s Qmini PCR can detect rabbit E. cuniculi in 90 minutes at your clinics using EDTA-blood or urine as samples.

For any direct inquiries, please contact us at: [email protected]

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To learn more about Qmini PCR, click here

About Bioguard Corporation

The Bioguard is a company focusing on animal disease diagnostic services and products.
Our animal health diagnostic center is the first and only ISO/ IEC 17025 accredited animal disease testing laboratory in Taiwan and China.

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